The most common type of Polyradiculoneuritis is Coonhound paralysis. This is similar to Guillain-Barré syndrome in humans. Coonhound paralysis seems to be secondary to a raccoon bite, probably due to some factor in the saliva. However, it can also occur without any interaction with a raccoon. It can happen in any breed of dog. When associated with a raccoon bite, the symptoms start 7 to 11 days after the bite, and include rear leg weakness progressing rapidly to paresis, and decreased reflexes. When not associated with a raccoon bite, the same symptoms occur, with the paresis taking about 3-4 days to reach it's maximum effect.

Severe cases will have a loss of bark, trouble breathing, and an inability to lift the head. Typically the duration of the paralysis is 2 to 3 months. However, the paralysis can last up to 6 months.

Treatment is proper nursing care, and the prognosis is good in mild cases. In bad cases the dog doesn't completely recover their initial muscular capability but still are able to live and enjoy life for years. In very bad cases it is possible for breathing to be impaired, and unless the dog is placed on a ventilator, suffocation will occur. Polyradiculoneuritis has also been seen one to two weeks post-vaccine in dogs and cats. It can also be caused by toxoplasmosis.